This paper presents a pilot project, developing at the University of Macerata and of the University Arizona, that is called “EduPlan4Inclusion”, oriented to implement accessibility in academic contents for all students, through the use of technology. The project wants to highlight the possible direction for Universities to balance the demands of an inclusive curriculum to a diverse student cohort within a technology-rich environment. In conclusion, the research proposes in this paper can be used to directly guide the reform of curriculum design and teaching methods in Colleges and Universities, with the aim to activate the possibility of implementing a more shared inclusive culture.