The data recently published in scientific literature identify in substance abuse the most important risk factor for the transmission of HCV. Another population at risk is represented by detainees, mainly because most of them have a history of substance use.
Treatment of the population at risk (substance users and detainees) must become a priority for health systems both to ensure fairness of access to care and to achieve the public health goal of eliminating HCV.
The programs to take charge should be multi-disciplinary, flexible, tailored, evidence-based, disseminated homogeneously throughout the national territory, and supported by procedures and guidelines including harm reduction actions, as suggested by the WHO.