Higher education institutions seek innovative teaching methodologies, investing in student protagonism in the teaching-learning process. Team-Based Learning (TBL) is an innovative alternative that allows students to expand their intellectual capacity, also promoting dynamic contact between groups involved. This study aimed to evaluate the academic performance and satisfaction of dental students, regarding this methodology. For the study of the academic performance, the statistical calculation of the averages of theoretical assessments of students submitted to the traditional teaching method and to the TBL method was used. For the analysis of students' opinions, a TBL assessment instrument was used. As a result, it was observed that the average of grades was higher in both semesters evaluated when using the TBL method compared to the traditional method, proving to be more efficient in the item yield according to grade, with statistically significant difference (p<0.01). The TBL method obtained satisfactory adherence by students, according to aspects of responsibility, method preference and student satisfaction.