The following paper faithfully reproduces the lectio magistralis that the two Prizker prize-winning architects Anne Lacaton and Jean-Philippe Vassal gave on 15 September 2023 in the classrooms of the Department of Architecture of the Università degli Studi Roma Tre, at the end of the immersive workshop Lacaton & Vassal @ TMB Salario: Reuse and new life cycle for the former TMB Salario area, which aimed to rethink the large waste treatment plant, decommissioned a few years ago. By presenting a review of their most significant projects, Anne Lacaton and Jean Philippe Vassal reconstructed, in words and images, their distinctive approach to design, respectful of what already exists and of those who already live there, but without ever renouncing the ambition, and the responsibility, of being able to generate and accompany a radical transformation of the existing, a metamorphosis.