Equipped with a strategic port but inserted in a difficult territory to settle, Genoa is an anomalous port-city, prosperous but fragile and exposed to exogenous crises. Its survival depends on external inputs, and its history is marked by entrepreneurial spirit and ability to reinvent itself after every crisis. For some time subject to a singular process of shrinkage, today the city is going through a period of transformation that is changing its physical structure, sees the appearance of actors hitherto extraneous to the local scene and the emergence of new practices. Whilst in some cases such practices have exceeded the limits of lawful, when considered as a whole they configure a new system of relations between public and private subjects, that can be of interest in a broader context.