The marginal territories require new tools to support the construction of policies capable of activating sustainable regeneration processes. This research, inspired by the ongoing political and scientific debate on Italian fragile areas, proposes the application of a hybrid methodological approach aimed at assessing territorial vulnerability, through an analysis that combines the potential of MCDA techniques with those of GIS. The research proposes the results of a first application of the proposed methodology, with a focus on the construction of value functions concerning the multiple dimensions of vulnerability. The analysis was carried out for the Italian
provinces of Alessandria and Vercelli, both crossed by the VENTO project, one of the longest Italian cycle paths with a great potential for relaunching the territories it crosses.