The link between psychiatric disorders and tobacco addiction is very close and has been evident for decades. On autism there is almost no trace in the international literature that relates to the subject. Our experience shows - even in cases of tobacco addiction related to psychiatric pathologies particularly connoted by the neurochemical effects of nicotine and by the gestural compulsion that the repeated consumption of tobacco satisfies - how an adequate and specific psycho-pharmacological setting, the correct training and involvement of a care-giver and long-term follow-up can allow the attainment of the cessation and the consolidation of this condition, with positive effects also on other aspects behavioral and subjective of the underlying pathology.