With this study we wanted to analyse a cohort of 135 patients who in the period beginning of the year 2014/february 2018 have reached our observation at Ser.T. in Voghera and Ser.T. of Pavia. These subjects have arrived at our services with problems related to the various forms of dependence, with more or less urgent needs related to the use and the abuse of substances, alcohol and with behaviours, lifestyles and pathologies related to them. After a first and cognitive interview, associated with a first and scrupulous analysis, a first reception is carried out. It was noted that they complained about some clinical and behavioural disorders typical of an important inner suffering, such as to be recognized and defined by a real request for “help” as in need of suggestive analyses and further investigations. It was therefore thought of a possible hospital evaluation to better study the cases and any related pathologies. The project is therefore exposed to the corporate management Asst of Pavia, which takes it into account, and collected by the Department of Internal Medicine of the hospital of Stradella. A collaborative, ductile, elastic, itinerant network is therefore created. A network of observation, protection, safety and rescue around the patient itself: the so-called “Car (a) vain”. It was then made arrangements and it began to evaluate patients individually. After about 45 months and in the light of the 135 patients studied, a mosaic of pathologies related to drug dependence and alcohol dependence came out with a suggestive clinical picture of further deepening of the project.