
Panic Disorder has not always been recognised as an exclusively psychiatric condition. Research in this area continued along medical and psychological axes until 1980, when the development of Diagnostic and Statistical Manual (DSM)-III criteria established the overall concept of panic disorder. This article briefly synthetizes the history of panic disorder until its current wording according to DSM-5 and provides elements of differential diagnosis with Panic Attacks, Agoraphobia andSubstance-Related and Addicitive Dosorders. The authors present a general framework for understanding the role of cognitions, emotions and physical symptoms in the pathogenesis of Panic Disorder. Recommendations for appropriate pharmacotherapy are also discussed.