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FrancoAngeli Journals

Contributi Scientifici

No. 74 (2026)

Naltrexone come trattamento off-label delle compulsività in pazienti con disturbi del neurosviluppo: descrizione di due casi clinici

DOI
https://doi.org/10.3280/mis74-2026oa23273
Submitted
luglio 15, 2026
Published
2026-07-27

Abstract

Introduction: Naltrexone is an opioid receptor antagonist approved for the treatment of alcohol and opioid use disorder. It has been explored off-label for the modulation of compulsive behaviors and impulse control.
In autism spectrum disorders (ASD), controlled studies have not shown consistent benefits on core symptoms; instead, heterogeneous results have been reported on associated behavioral manifestations.
Case presentation: We report two cases.

Conclusions: In selected patients with neurodevelopmental disorders and clinically significant compulsivity, naltrexone may be an off-label, symptom-targeted adjunct option; prospective studies with standardized measures are needed.

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