The study focuses on the adoption of artificial intelligence (AI) tools in healthcare organisations and analyses the determinants of adoption by healthcare professionals. Although the adoption of new technologies, and, in particular, emerging technologies such as AI, can offer innovative solutions to improve patient health and the efficiency of healthcare organisations, their adoption can be hindered by the emergence of possible organisational, individual and professional resistance. Based on the TOE framework and through the use of NVivo, semi-structured interviews with Italian hospital pharmacists were conducted and analysed. The work provides new evidence on the adoption of emerging technologies in the healthcare sector and identifies the main determinants that decision-makers should consider in order to promote the implementation of AI technologies. The findings provide useful information for technology providers, policy makers and managers in developing more appropriate strategies to facilitate the adoption of such technologies in the healthcare system.