This contribution aims to provide an overview of green management strategies applied by healthcare organizations to reduce environmental footprint, deepening the green practices adopted by Humanitas Research Hospital. The article first explains the main environmental challenges faced by the healthcare sector and the International and European policies in this field. Second, it identifies three categories of practices that characterize green management: waste management, green building, and energy & water consumption management. Then, the study analyses the practices adopted by Humanitas Research Hospital for each of the three levers, highlighting that green management practices embedded in corporate strategy can improve the efficiency of operations and build a more sustainable environment to protect the health of patients and personnel.