In this paper is presented a clinical study of a limited-time outpatient group with a focus on interpersonal problems. This study was realized using the MacKenzie’s model that has conceptualized a closed psychotherapeutic group to adapt short and focal interventions to public health. With this article we intend to explain the use of the group of interpersonal problems and to show how individual and group outcome measures can be a support to clinical practice. Furthermore, we want to show how the anxious and depressive symptoms of mood disorders can be treated with a group model that focuses on current interpersonal relationships. There are only a few exclusion criteria for the group of interpersonal problems: conduct disorders, acute phase due to separation, grief or suicidality, significative characteristics of borderline personality disorder. In conclusion, the study shows that the group of interpersonal problems represent a treatment for a large and difficult population of patients in the area of public mental health.