During the Renaissance, the city became a reflection of rationality and order, including political order. On different scales, according to individual places, this is what happened in the Abruzzi territories ruled by Margaret of Austria, the natural daughter of Charles V. She became the promoter of a very clear urban logic, aimed at centralised control and a means through which to launch a broader state project that harked back to the myth of the good Renaissance prince. The study we propose will attempt to reconstruct the intentions and interventions desired by the sovereign to redevelop, from an urbanistic point of view, certain towns in Abruzzo and the city of L’Aquila, of which Margaret was Governor. Thanks to this analysis, it is possible to observe relevant episodes of cultural transfer in scenarios that, due to decentralisation and political context, could have been entirely oriented by female power, especially when compared to the periods spent by Margaret in ‘her’ capitals (L’Aquila, Cittaducale and Ortona).