Pnei Review, the official journal of the Italian Society of Psychoneuroendocrineimmunology, a scientific society recognised by the Italian Ministry of Health, which has been active for 25 years in the field of research, teaching and scientific dissemination of the PNEI paradigm, published by Franco Angeli, Milan, aims to disseminate the systemic paradigm of Psychoneuroendocrineimmunology, which forms the basis for the integration of medical and psychological sciences and practices. Integration between medicine and psychology, which is mature on a scientific level and is desired by relevant sectors of practitioners and users to overcome the spiral of rising costs-modest efficacy of treatments based on the reductionist drug-centric model. The accumulation of knowledge and experience on the integration of psychology and medicine, in turn, is essential for the development of the Psychoneuroendocrineimmunology (PNEI) paradigm itself.

Psychoneuroendocrineimmunology, in fact, is not Neuroendocrineimmunology. PNEI describes the relationships of mutual influence between psyche and biological systems, showing the scientific inconsistency of the reductionist dogma that makes the psyche a mere epiphenomenon of brain activity.

We are in a phase of research that allows the definitive overcoming of the dualistic conception of the human being without falling into the trap of the mind-brain identity, in the reduction of the psychic dimension to the biological one, from which it undoubtedly originates but on which it influences from the early stages of individual life. To this end, it is essential to criticise the philosophical foundations of contemporary reductionism and, at the same time, present the scientific evidence documenting the mutual influence of psyche and biological systems in health and illness.

Pnei Review will host integrated knowledge synthesis works on the functioning of the human network, essential for understanding, in a non-reductionistic way, the dynamics of health and disease and thus build a dynamic pathophysiological vision, open to molecular updates and preventive and therapeutic strategies. The compartmentalisation of knowledge must be overcome because it is an obstacle to understanding the pathogenesis and to proposing personalised therapies, without underestimating, indeed enhancing, the study of the molecular dimension, which, with epigenetics, shows that even the genome is flexible and responsive to the environment and behaviour.

In Pnei Review we therefore welcome reviews (narrative, purposive, systematic) and research original research in the field of human pathophysiology and in the integration of medicine and psychology. Also welcome are scientific papers documenting the role of behaviour (nutrition, physical activity, stress and emotion management, sleep), of the socio-environmental conditions (inequalities, pollution, climate change), of complementary therapeutic methods with scientific evidence (phytotherapy, acupuncture meditation, mind-body techniques, osteopathy), in prevention and therapy. It will also host and will also actively seek opinions, comments, essays on the philosophical and cultural foundations of PNEI and related disciplines (psychology, sociology, neuroscience, endocrinology, immunology, epigenetics and molecular biology).