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Essays

Vol. 158 No. 2 (2025): Rendiconti. Mathematics and Natural Sciences Class

Structural biology and artificial intelligence: a multidisciplinary revolution in understanding protein structures

  • Federico Forneris
DOI
https://doi.org/10.3280/rndoa2025oa21153
Submitted
ottobre 1, 2025
Published
2026-02-17

Abstract

Structural biology is a fascinating and constantly evolving discipline that focuses on studying the three-dimensional structure of biological macromolecules and their relationship with cellular functions. Through advanced experimental and computational techniques, researchers progressively gain a deeper understanding of the molecular mechanisms that govern life. This knowledge has direct implications for human health by shedding light on the molecular basis of various diseases, opening up innovative perspectives for the development of targeted and effective drugs. The following presentation aims to provide an introduction to structural biology, with particular emphasis on the problem of protein folding and the revolutionary impact that artificial intelligence has had in this field in recent years. In relation to this topic, and to highlight how AI-based tools can serve as a valuable resource for scientific research when used appropriately, I would like to clarify that I have utilized artificial intelligence tools in drafting this text. Specifically, the first draft of this presentation was generated by the ChatGPT software based on the transcription of a talk given at the Lombard Institute. This transcription was also obtained using artificial intelligence by analyzing the recording of the talk available on YouTube through the Panopto software.

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