
The paper provides the scientific community and the clinic practitioners dealing with neurodevelopmental disorders with a list of open questions about research and diagnosis. Such questions are elicited by the evidence coming from neuroscience investigations and from the outline of a different framework to understand disorders with onset in the developmental period. The broad heterogeneity that characterizes the diagnostic categories of neurodevelopmental disorders has favored the emergence of constructs referable to complexity, multidimensionality, and comorbidity. The reflection is carried-out according to the Research Domain Criteria (RDoC) approach. RDoC is a dimensional diagnostic system with the aim of shifting the focus of research and clinical practice away from the existing diagnostic categories towards dimensions of observable behavior and neurobiological measures. The transdiagnostic perspective of the RDoc approach is used here both as a possible criticism of the dominant research paradigms and as a challenge to rethink neurodevelopmental disorders and as a potential solution to intercept the specificities of the phenotypes.