Salta al menu principale di navigazione Salta al contenuto principale Salta al piè di pagina del sito
FrancoAngeli Journals

Sez. generale - Studi e ricerche

N. 51 (2022)

Neurobiologia del cervello sociale nei disturbi d’ansia e dell’umore – Mini-review

DOI
https://doi.org/10.3280/qpc51-2022oa15181
Inviata
9 gennaio 2023
Pubblicato
18-01-2023

Abstract

La conoscenza attuale permette di tracciare un iniziale quadro dei complessi substrati neurobiologici che sostengono il funzionamento del cervello sociale negli umani. L’alta complessità del cervello sociale determina tuttavia un’alta vulnerabilità verso diversi disturbi neuropsichiatrici.
Nel presente articolo, ci siamo focalizzati sulle disfunzioni sociali presenti nei principali disturbi dell’umore e di ansia, descrivendo i substrati neurobiologici che sono stati associati a tali deficit. È interessante notare che tali substrati risultano simili in questi disturbi e simili a quelli riscontrati in altri disturbi neuropsichiatrici, seppure risultino impattati in misura diversa nelle diverse condizioni. Perciò, le disfunzioni sociali potrebbero rappresentare un dominio (parzialmente) indipendente con specifiche alterazioni biologiche alla sua base.
Una migliore comprensione di tali basi neurobiologiche potrebbe aprire la strada allo sviluppo di trattamenti mirati per tali deficit.

Riferimenti bibliografici

  1. Aa.Vv. (2014). Psychosis and schizophrenia in adults: prevention and management. London: National Institute for Health and Care Excellence (NICE).
  2. Abu-Akel, A. & Shamay-Tsoory, S. (2011). Neuroanatomical and neurochemical bases of theory of mind. [Review]. Neuropsychologia, 49(11): 2971-2984. DOI: 10.1016/j.neuropsychologia.2011.07.012.
  3. Adolphs, R. (2009). The social brain: neural basis of social knowledge. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Review]. Annual Review of Psychology, 60: 693-716. DOI: 10.1146/annurev.psych.60.110707.163514.
  4. Adolphs, R., Tranel, D., Damasio, H. & Damasio, A.R. (1995). Fear and the human amygdala. [Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, P.H.S.]. Journal of Neuroscience, 15(9): 5879-5891.
  5. Almeida, J.R., Versace, A., Mechelli, A., Hassel, S., Quevedo, K., Kupfer, D.J. & Phillips, M.L. (2009). Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Biological Psychiatry, 66(5): 451-459. DOI: 10.1016/j.biopsych.2009.03.024.
  6. Alvares, G.A., Hickie, I.B. & Guastella, A.J. (2010). Acute effects of intranasal oxytocin on subjective and behavioral responses to social rejection. [Randomized Controlled Trial Research Support, Non-U.S. Gov’t]. Experimental and Clinical Psychopharmacology, 18(4): 316-321. DOI: 10.1037/a0019719.
  7. Anaya, C., Torrent, C., Caballero, F.F., Vieta, E., Bonnin Cdel, M. & Ayuso-Mateos, J.L. (2016). Cognitive reserve in bipolar disorder: relation to cognition, psychosocial functioning and quality of life. [Research Support, Non-U.S. Gov’t]. Acta Psychiatrica Scandinavica, 133(5): 386-398. DOI: 10.1111/acps.12535.
  8. Andrews-Hanna, J.R., Reidler, J.S., Sepulcre, J., Poulin, R. & Buckner, R.L. (2010). Functional-anatomic fractionation of the brain’s default network. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Neuron, 65(4): 550-562. DOI: 10.1016/j.neuron.2010.02.005.
  9. Ba, Z., Chen, M., Lai, J., Liao, Y., Fang, H., Lu, D., … Lin, X. (2022). Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables. Frontiers in Psychiatry, 13: 900757. DOI: 10.3389/fpsyt.2022.900757.
  10. Balleine, B.W. & O’Doherty, J.P. (2010). Human and rodent homologies in action control: corticostriatal determinants of goal-directed and habitual action. [Research Support, N.I.H., Extramural Review]. Neuropsychopharmacology, 35(1): 48-69. DOI: 10.1038/npp.2009.131.
  11. Barak, B. & Feng, G. (2016). Neurobiology of social behavior abnormalities in autism and Williams syndrome. [Review]. Nature Neuroscience, 19(6): 647-655. DOI: 10.1038/nn.4276.
  12. Baribeau, D.A. & Anagnostou, E. (2015). Oxytocin and vasopressin: linking pituitary neuropeptides and their receptors to social neurocircuits. [Review]. Frontiers in Neuroscience, 9: 335. DOI: 10.3389/fnins.2015.00335.
  13. Barrett, L.F. & Satpute, A.B. (2013). Large-scale brain networks in affective and social neuroscience: towards an integrative functional architecture of the brain. [Research Support, N.I.H., Extramural Research Support, U.S. Gov’t, Non-P.H.S. Review]. Current Opinion in Neurobiology, 23(3): 361-372. DOI: 10.1016/j.conb.2012.12.012.
  14. Bartlett, A.A., Singh, R. & Hunter, R.G. (2017). Anxiety and Epigenetics. [Review]. Advances in Experimental Medicine and Biology, 978: 145-166. DOI: 10.1007/978-3-319-53889-1_8.
  15. Beesdo-Baum, K., Knappe, S., Fehm, L., Hofler, M., Lieb, R., Hofmann, S.G. & Wittchen, H.U. (2012). The natural course of social anxiety disorder among adolescents and young adults. [Research Support, Non-U.S. Gov’t]. Acta Psychiatrica Scandinavica, 126(6): 411-425. DOI: 10.1111/j.1600-0447.2012.01886.x.
  16. Bergan, J.F. (2015). Neural Computation and Neuromodulation Underlying Social Behavior. [Research Support, Non-U.S. Gov’t Review]. Integrative and Comparative Biology, 55(2): 268-280. DOI: 10.1093/icb/icv061.
  17. Bershad, A.K., Miller, M.A., Baggott, M.J. & de Wit, H. (2016). The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants? [Review]. Journal of Psychopharmacology, DOI: 10.1177/0269881116663120.
  18. Bickart, K.C. Brickhouse, M., Negreira A., Sapolsky D., Feldman Barrett, L., Dickerson B.C. (2014a). Atrophy in distinct corticolimbic networks in frontotemporal dementia relates to social impairments measured using the Social Impairment Rating Scale. Journal of Neurology, Neurosurgery and Psychiatry, 85(4): 438-448. DOI: 10.1136/jnnp-2012-304656.
  19. Bickart, K.C., Dickerson, B.C. & Barrett, L.F. (2014b). The amygdala as a hub in brain networks that support social life. [Research Support, N.I.H., Extramural Review]. Neuropsychologia, 63: 235-248. DOI: 10.1016/j.neuropsychologia.2014.08.013.
  20. Bickart, K.C., Hollenbeck, M.C., Barrett, L.F. & Dickerson, B.C. (2012). Intrinsic amygdala-cortical functional connectivity predicts social network size in humans. [Research Support, N.I.H., Extramural]. Journal of Neuroscience, 32(42): 14729-14741. DOI: 10.1523/JNEUROSCI.1599-12.2012.
  21. Bicks, L.K., Koike, H., Akbarian, S. & Morishita, H. (2015). Prefrontal Cortex and Social Cognition in Mouse and Man. [Review]. Frontiers in Psychology, 6: 1805. DOI: 10.3389/fpsyg.2015.01805.
  22. Bierman, K.L. & Welsh, J.A. (2000). Assessing social dysfunction: the contributions of laboratory and performance-based measures. [Review]. Journal of Clinical Child & Adolescent Psychology, 29(4): 526-539. DOI: 10.1207/S15374424JCCP2904_6.
  23. Black, J.J., Clark, D.B., Martin, C.S., Kim, K.H., Blaze, T.J., Creswell, K.G. & Chung, T. (2015). Course of alcohol symptoms and social anxiety disorder from adolescence to young adulthood. [Research Support, N.I.H., Extramural]. Alcoholism: Clinical and Experimental Research, 39(6): 1008-1015. DOI: 10.1111/acer.12711.
  24. Blass, E.M. & Fitzgerald, E. (1988). Milk-induced analgesia and comforting in 10-day-old rats: opioid mediation. [Research Support, U.S. Gov’t, P.H.S.]. Pharmacology, Biochemistry and Behavior, 29(1): 9-13.
  25. Bora, E. & Berk, M. (2016). Theory of mind in major depressive disorder: A meta-analysis. [Meta-Analysis Review]. Journal of Affective Disorders, 191: 49-55. DOI: 10.1016/j.jad.2015.11.023.
  26. Bowie, C.R., Leung, W.W., Reichenberg, A., McClure, M.M., Patterson, T.L., Heaton, R.K. & Harvey, P.D. (2008). Predicting schizophrenia patients’ real-world behavior with specific neuropsychological and functional capacity measures. [Research Support, N.I.H., Extramural Research Support, U.S. Gov’t, Non-P.H.S.]. Biological Psychiatry, 63(5): 505-511. DOI: 10.1016/j.biopsych.2007.05.022.
  27. Bowie, C.R., Reichenberg, A., Patterson, T.L., Heaton, R.K. & Harvey, P.D. (2006). Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms. [Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. The American Journal of Psychiatry, 163(3): 418-425. DOI: 10.1176/appi.ajp.163.3.418.
  28. Brothers, L. (1990). The neural basis of primate social communication. Motivation and Emotion, 14(2): 81-91.
  29. Brotman, M.A., Tseng, W.L., Olsavsky, A.K., Fromm, S.J., Muhrer, E.J., Rutenberg, J.G., … Leibenluft, E. (2014). Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands. [Research Support, N.I.H., Intramural]. Psychological Medicine, 44(8): 1639-1651. DOI: 10.1017/S003329171300202X.
  30. Buckholtz, J.W., Asplund, C.L., Dux, P.E., Zald, D.H., Gore, J.C., Jones, O.D. & Marois, R. (2008). The neural correlates of third-party punishment. [Research Support, Non-U.S. Gov’t]. Neuron, 60(5): 930-940. DOI: 10.1016/j.neuron.2008.10.016.
  31. Buckner, J.D. & Turner, R.J. (2009). Social anxiety disorder as a risk factor for alcohol use disorders: a prospective examination of parental and peer influences. [Comparative Study] [Research Support, N.I.H., Extramural]. Drug and Alcohol Dependence, 100(1-2): 128-137. DOI: 10.1016/j.drugalcdep.2008.09.018.
  32. Buckner, R.L., Andrews-Hanna, J.R. & Schacter, D.L. (2008). The brain’s default network: anatomy, function, and relevance to disease. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Review]. Annals of the New York Academy of Sciences, 1124, 1-38. DOI: 10.1196/annals.1440.011.
  33. Burdick, K.E., Russo, M., Frangou, S., Mahon, K., Braga, R.J., Shanahan, M. & Malhotra, A.K. (2014). Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications. [Research Support, N.I.H., Extramural]. Psychological Medicine, 44(14): 3083-3096. DOI: 10.1017/S0033291714000439.
  34. Burkner, P.C., Williams, D.R., Simmons, T.C. & Woolley, J.D. (2017). Intranasal Oxytocin May Improve High-Level Social Cognition in Schizophrenia, But Not Social Cognition or Neurocognition in General: A Multilevel Bayesian Meta-analysis. [Meta-Analysis]. Schizophrenia Bulletin, 43(6): 1291-1303. DOI: 10.1093/schbul/sbx053.
  35. Cacioppo, J.T. & Hawkley, L.C. (2009). Perceived social isolation and cognition. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Review]. Trends in Cognitive Sciences, 13(10): 447-454. DOI: 10.1016/j.tics.2009.06.005.
  36. Caouette, J.D. & Guyer, A.E. (2014). Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience. [Research Support, N.I.H., Extramural Review]. Developmental cognitive neuroscience, 8: 65-76. DOI: 10.1016/j.dcn.2013.10.003.
  37. Carson, D.S., Berquist, S.W., Trujillo, T.H., Garner, J.P., Hannah, S.L., Hyde, S.A., … Parker, K.J. (2015). Cerebrospinal fluid and plasma oxytocin concentrations are positively correlated and negatively predict anxiety in children. [Research Support, N.I.H., Extramural]. Molecular Psychiatry, 20(9): 1085-1090. DOI: 10.1038/mp.2014.132.
  38. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., … Poulton, R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. [Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, P.H.S.]. Science, 301(5631): 386-389. DOI: 10.1126/science.1083968.
  39. Challis, C. & Berton, O. (2015). Top-Down Control of Serotonin Systems by the Prefrontal Cortex: A Path toward Restored Socioemotional Function in Depression. [Research Support, N.I.H., Extramural Review]. ACS Chemical Neuroscience, 6(7): 1040-1054. DOI: 10.1021/acschemneuro.5b00007.
  40. Challis, C., Boulden, J., Veerakumar, A., Espallergues, J., Vassoler, F.M., Pierce, R.C., … Berton, O. (2013). Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Journal of Neuroscience, 33(35): 13978-13988, 13988a. DOI: 10.1523/JNEUROSCI.2383-13.2013.
  41. Chaudhury, D., Walsh, J.J., Friedman, A.K., Juarez, B., Ku, S.M., Koo, J.W., … Han, M.H. (2013). Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Nature, 493(7433): 532-536. DOI: 10.1038/nature11713.
  42. Chelnokova, O., Laeng, B., Eikemo, M., Riegels, J., Loseth, G., Maurud, H., … Leknes, S. (2014). Rewards of beauty: the opioid system mediates social motivation in humans. [Controlled Clinical Trial Letter Research Support, N.I.H., Extramural]. Molecular Psychiatry, 19(7): 746-747. DOI: 10.1038/mp.2014.1.
  43. Ching, C.R.K., Hibar, D.P., Gurholt, T.P., Nunes, A., Thomopoulos, S.I., Abe, C., … Andreassen, O.A. (2022). What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. [Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov’t Review]. Human Brain Mapping, 43(1): 56-82. DOI: 10.1002/hbm.25098.
  44. Chou, M.Y., Amo, R., Kinoshita, M., Cherng, B.W., Shimazaki, H., Agetsuma, M., … Okamoto, H. (2016). Social conflict resolution regulated by two dorsal habenular subregions in zebrafish. [Research Support, Non-U.S. Gov’t]. Science, 352(6281): 87-90. DOI: 10.1126/science.aac9508.
  45. Cohen Kadosh, K., Cohen Kadosh, R., Dick, F. & Johnson, M.H. (2011). Developmental changes in effective connectivity in the emerging core face network. [Research Support, Non-U.S. Gov’t]. Cerebral Cortex, 21(6): 1389-1394. DOI: 10.1093/cercor/bhq215.
  46. Conson, M., Errico, D., Mazzarella, E., Giordano, M., Grossi, D. & Trojano, L. (2015). Transcranial Electrical Stimulation over Dorsolateral Prefrontal Cortex Modulates Processing of Social Cognitive and Affective Information. [Randomized Controlled Trial]. PLoS One, 10(5): e0126448. DOI: 10.1371/journal.pone.0126448.
  47. Coria-Avila, G.A., Manzo, J., Garcia, L.I., Carrillo, P., Miquel, M. & Pfaus, J.G. (2014). Neurobiology of social attachments. [Research Support, Non-U.S. Gov’t Review]. Neuroscience & Biobehavioral Reviews, 43: 173-182. DOI: 10.1016/j.neubiorev.2014.04.004.
  48. Cosmides, L. & Tooby, J. (1992) Cognitive Adaptations for Social Exchange (pp. 163-228). In: J.H. Barkow, L. Cosmides, J. Tooby (eds.), The Adapted Mind: Evolutionary Psychology and the Generation of Culture. Oxford: Oxford University Press.
  49. Cotter, J., Granger, K., Backx, R., Hobbs, M., Looi, C.Y. & Barnett, J.H. (2018). Social cognitive dysfunction as a clinical marker: A systematic review of meta-analyses across 30 clinical conditions. [Meta-Analysis Review Systematic Review]. Neuroscience & Biobehavioral Reviews, 84: 92-99. DOI: 10.1016/j.neubiorev.2017.11.014.
  50. Cusi, A.M., Nazarov, A., Holshausen, K., Macqueen, G.M. & McKinnon, M.C. (2012). Systematic review of the neural basis of social cognition in patients with mood disorders. [Meta-Analysis Research Support, Non-U.S. Gov’t Review Systematic Review]. Journal of Psychiatry & Neuroscience, 37(3): 154-169. DOI: 10.1503/jpn.100179.
  51. Cuthbert, B.N. (2015). Research Domain Criteria: toward future psychiatric nosologies. [Review]. Dialogues in Clinical Neuroscience, 17(1): 89-97.
  52. Dabrowska, J., Hazra, R., Ahern, T.H., Guo, J.D., McDonald, A.J., Mascagni, F., … Rainnie, D.G. (2011). Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect. [Research Support, N.I.H., Extramural Research Support, U.S. Gov’t, Non-P.H.S.]. Psychoneuroendocrinology, 36(9): 1312-1326. DOI: 10.1016/j.psyneuen.2011.03.003.
  53. Dalili, M.N., Penton-Voak, I.S., Harmer, C.J. & Munafo, M.R. (2015). Meta-analysis of emotion recognition deficits in major depressive disorder. [Meta-Analysis Research Support, Non-U.S. Gov’t]. Psychological Medicine, 45(6): 1135-1144. DOI: 10.1017/S0033291714002591.
  54. Derntl, B., Seidel, E.M., Eickhoff, S.B., Kellermann, T., Gur, R.C., Schneider, F. & Habel, U. (2011). Neural correlates of social approach and withdrawal in patients with major depression. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Society for Neuroscience, 6(5-6): 482-501. DOI: 10.1080/17470919.2011.579800.
  55. Dickerson, B.C. (2015). Dysfunction of social cognition and behavior. [Case Reports Review]. Continuum, 21(3): 660-677. DOI: 10.1212/01.CON.0000466659.05156.1d.
  56. Dirks, M.A., Treat, T.A. & Weersing, V.R. (2007). Integrating theoretical, measurement, and intervention models of youth social competence. [Research Support, Non-U.S. Gov’t Review]. Clinical Psychology Review, 27(3): 327-347. DOI: 10.1016/j.cpr.2006.11.002.
  57. Dolen, G., Darvishzadeh, A., Huang, K.W. & Malenka, R.C. (2013). Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Nature, 501(7466): 179-184. DOI: 10.1038/nature12518.
  58. Domes, G., Heinrichs, M., Glascher, J., Buchel, C., Braus, D.F. & Herpertz, S.C. (2007). Oxytocin attenuates amygdala responses to emotional faces regardless of valence. [Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov’t]. Biological Psychiatry, 62(10): 1187-1190. DOI: 10.1016/j.biopsych.2007.03.025.
  59. Domes, G., Schulze, L. & Herpertz, S.C. (2009). Emotion recognition in borderline personality disorder-a review of the literature. [Research Support, Non-U.S. Gov’t Review]. Journal of Personality Disorders, 23(1): 6-19. DOI: 10.1521/pedi.2009.23.1.6.
  60. Dunbar, R.I. (2009). The social brain hypothesis and its implications for social evolution. [Addresses]. Annals of Human Biology, 36(5): 562-572. DOI: 10.1080/03014460902960289.
  61. Dunbar, R.I. & Shultz, S. (2007). Evolution in the social brain. [Review]. Science, 317(5843): 1344-1347. DOI: 10.1126/science.1145463.
  62. Dunsmoor, J.E. & Paz, R. (2015). Fear Generalization and Anxiety: Behavioral and Neural Mechanisms. [Research Support, Non-U.S. Gov’t Review]. Biological Psychiatry, 78(5): 336-343. DOI: 10.1016/j.biopsych.2015.04.010.
  63. Eisenberger, N.I. (2012). The pain of social disconnection: examining the shared neural underpinnings of physical and social pain. [Review]. Nature Reviews Neuroscience, 13(6): 421-434. DOI: 10.1038/nrn3231.
  64. Essau, C.A., Lewinsohn, P.M., Olaya, B. & Seeley, J.R. (2014). Anxiety disorders in adolescents and psychosocial outcomes at age 30. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Journal of Affective Disorders, 163, 125-132. DOI: 10.1016/j.jad.2013.12.033.
  65. Fett, A.K., Viechtbauer, W., Dominguez, M.D., Penn, D.L., van Os, J. & Krabbendam, L. (2011). The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. [Meta-Analysis Research Support, Non-U.S. Gov’t Review]. Neuroscience & Biobehavioral Reviews, 35(3): 573-588. DOI: 10.1016/j.neubiorev.2010.07.001.
  66. File, S.E. & Seth, P. (2003). A review of 25 years of the social interaction test. [Review]. European Journal of Pharmacology, 463(1-3): 35-53.
  67. Foland, L.C., Altshuler, L.L., Bookheimer, S.Y., Eisenberger, N., Townsend, J. & Thompson, P.M. (2008). Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Psychiatry Research, 162(1): 27-37. DOI: 10.1016/j.pscychresns.2007.04.007.
  68. Fox, N.A., Henderson, H.A., Marshall, P.J., Nichols, K.E. & Ghera, M.M. (2005). Behavioral inhibition: linking biology and behavior within a developmental framework. [Review]. Annual Review of Psychology, 56: 235-262. DOI: 10.1146/annurev.psych.55.090902.141532.
  69. Frith, C.D. & Frith, U. (2006). The neural basis of mentalizing. [Comment Review]. Neuron, 50(4): 531-534. DOI: 10.1016/j.neuron.2006.05.001.
  70. Fudge, J.L., Kelly, E.A., Pal, R., Bedont, J.L., Park, L. & Ho, B. (2017). Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate. Neuropsychopharmacology, 42(8): 1563-1576. DOI: 10.1038/npp.2017.38.
  71. Gillissie, E.S., Lui, L.M.W., Ceban, F., Miskowiak, K., Gok, S., Cao, B., … McIntyre, R.S. (2022). Deficits of social cognition in bipolar disorder: Systematic review and meta-analysis. [Meta-Analysis Review Systematic Review]. Bipolar Disorders, 24(2): 137-148. DOI: 10.1111/bdi.13163.
  72. Gkika, S., Wittkowski, A. & Wells, A. (2018). Social cognition and metacognition in social anxiety: A systematic review. [Review Systematic Review]. Clinical Psychology & Psychotherapy, 25(1): 10-30. DOI: 10.1002/cpp.2127.
  73. Glaser, Y.G., Zubieta, J.K., Hsu, D.T., Villafuerte, S., Mickey, B.J., Trucco, E.M., … Heitzeg, M.M. (2014). Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex. [Research Support, N.I.H., Extramural]. Journal of Neuroscience, 34(11): 4099-4107. DOI: 10.1523/JNEUROSCI.3672-13.2014.
  74. Gradin, V.B., Perez, A., Macfarlane, J.A., Cavin, I., Waiter, G., Tone, E.B., … Steele, J.D. (2016). Neural correlates of social exchanges during the Prisoner’s Dilemma game in depression. [Research Support, Non-U.S. Gov’t]. Psychological Medicine, 46(6): 1289-1300. DOI: 10.1017/S0033291715002834.
  75. Green, M.F., Horan, W.P. & Lee, J. (2015). Social cognition in schizophrenia. [Review]. Nature Reviews Neuroscience, 16(10): 620-631. DOI: 10.1038/nrn4005.
  76. Green, M.F. & Leitman, D.I. (2008). Social cognition in schizophrenia. Schizophrenia Bulletin, 34(4): 670-672. DOI: 10.1093/schbul/sbn045.
  77. Groenewold, N.A., Opmeer, E.M., de Jonge, P., Aleman, A. & Costafreda, S.G. (2013). Emotional valence modulates brain functional abnormalities in depression: evidence from a meta-analysis of fMRI studies. [Meta-Analysis Research Support, Non-U.S. Gov’t Review]. Neuroscience & Biobehavioral Reviews, 37(2): 152-163. DOI: 10.1016/j.neubiorev.2012.11.015.
  78. Groppe, S.E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Grunder, G. & Spreckelmeyer, K.N. (2013). Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain. [Randomized Controlled Trial Research Support, Non-U.S. Gov’t]. Biological Psychiatry, 74(3): 172-179. DOI: 10.1016/j.biopsych.2012.12.023.
  79. Guastella, A.J., Mitchell, P.B. & Mathews, F. (2008). Oxytocin enhances the encoding of positive social memories in humans. [Randomized Controlled Trial]. Biological Psychiatry, 64(3): 256-258. DOI: 10.1016/j.biopsych.2008.02.008.
  80. Gunaydin, L.A., Grosenick, L., Finkelstein, J.C., Kauvar, I.V., Fenno, L.E., Adhikari, A., … Deisseroth, K. (2014). Natural neural projection dynamics underlying social behavior. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, Non-P.H.S.]. Cell, 157(7): 1535-1551. DOI: 10.1016/j.cell.2014.05.017.
  81. Guyer, A.E., Choate, V.R., Detloff, A., Benson, B., Nelson, E.E., Perez-Edgar, K., … Ernst, M. (2012). Striatal functional alteration during incentive anticipation in pediatric anxiety disorders. [Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural]. The American Journal of Psychiatry, 169(2): 205-212. DOI: 10.1176/appi.ajp.2011.11010006.
  82. Hamm, L.L., Jacobs, R.H., Johnson, M.W., Fitzgerald, D.A., Fitzgerald, K.D., Langenecker, S.A., … Phan, K.L. (2014). Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders. Biology of Mood & Anxiety Disorders, 4(1): 15. DOI: 10.1186/s13587-014-0015-4.
  83. Hampton, W.H., Unger, A., Von Der Heide, R.J. & Olson, I.R. (2016). Neural connections foster social connections: a diffusion-weighted imaging study of social networks. [Research Support, N.I.H., Extramural]. Social Cognitive and Affective Neuroscience, 11(5): 721-727. DOI: 10.1093/scan/nsv153.
  84. Hariri, A.R., Mattay, V.S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., … Weinberger, D.R. (2002). Serotonin transporter genetic variation and the response of the human amygdala. [Comparative Study]. Science, 297(5580): 400-403. DOI: 10.1126/science.1071829.
  85. Haro, J.M., Kahle-Wrobleski, K., Bruno, G., Belger, M., Dell’Agnello, G., Dodel, R., … Argimon, J.M. (2014). Analysis of burden in caregivers of people with Alzheimer’s disease using self-report and supervision hours. [Multicenter Study Observational Study Research Support, Non-U.S. Gov’t]. The Journal of Nutrition, Health and Aging, 18(7): 677-684. DOI: 10.1007/s12603-014-0036-0.
  86. Haro, J.M., Reed, C., Gonzalez-Pinto, A., Novick, D., Bertsch, J. & Vieta, E. (2011). 2-Year course of bipolar disorder type I patients in outpatient care: factors associated with remission and functional recovery. [Research Support, Non-U.S. Gov’t]. European Neuropsychopharmacology, 21(4): 287-293. DOI: 10.1016/j.euroneuro.2010.08.001.
  87. Hattingh, C.J., Ipser, J., Tromp, S.A., Syal, S., Lochner, C., Brooks, S.J. & Stein, D.J. (2012). Functional magnetic resonance imaging during emotion recognition in social anxiety disorder: an activation likelihood meta-analysis. Frontiers in Human Neuroscience, 6: 347. DOI: 10.3389/fnhum.2012.00347.
  88. Herry, C., Bach, D.R., Esposito, F., Di Salle, F., Perrig, W.J., Scheffler, K., … Seifritz, E. (2007). Processing of temporal unpredictability in human and animal amygdala. [Comparative Study Research Support, Non-U.S. Gov’t]. Journal of Neuroscience, 27(22): 5958-5966. DOI: 10.1523/JNEUROSCI.5218-06.2007.
  89. Hooley, J.M., Gruber, S.A., Scott, L.A., Hiller, J.B. & Yurgelun-Todd, D.A. (2005). Activation in dorsolateral prefrontal cortex in response to maternal criticism and praise in recovered depressed and healthy control participants. [Comparative Study Research Support, Non-U.S. Gov’t]. Biological Psychiatry, 57(7): 809-812. DOI: 10.1016/j.biopsych.2005.01.012.
  90. Horacek, J., Mikolas, P., Tintera, J., Novak, T., Palenicek, T., Brunovsky, M., … Alda, M. (2015). Sad mood induction has an opposite effect on amygdala response to emotional stimuli in euthymic patients with bipolar disorder and healthy controls. [Research Support, Non-U.S. Gov’t]. Journal of Psychiatry & Neuroscience, 40(2): 134-142.
  91. Hostinar, C.E., Sullivan, R.M. & Gunnar, M.R. (2014). Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Review]. Psychological Bulletin, 140(1): 256-282. DOI: 10.1037/a0032671.
  92. Hsu, D.T., Sanford, B.J., Meyers, K.K., Love, T.M., Hazlett, K.E., Walker, S.J., … Zubieta, J.K. (2015). It still hurts: altered endogenous opioid activity in the brain during social rejection and acceptance in major depressive disorder. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Molecular Psychiatry, 20(2): 193-200. DOI: 10.1038/mp.2014.185.
  93. Hsu, D.T., Sanford, B.J., Meyers, K.K., Love, T.M., Hazlett, K.E., Wang, H., … Zubieta, J.K. (2013). Response of the mu-opioid system to social rejection and acceptance. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Molecular Psychiatry, 18(11): 1211-1217. DOI: 10.1038/mp.2013.96.
  94. Hulvershorn, L.A., Karne, H., Gunn, A.D., Hartwick, S.L., Wang, Y., Hummer, T.A. & Anand, A. (2012). Neural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania. [Research Support, N.I.H., Extramural]. Biological Psychiatry, 71(7): 603-610. DOI: 10.1016/j.biopsych.2011.10.038.
  95. Hyatt, C.J., Calhoun, V.D., Pearlson, G.D. & Assaf, M. (2015). Specific default mode subnetworks support mentalizing as revealed through opposing network recruitment by social and semantic FMRI tasks. [Research Support, N.I.H., Extramural]. Human Brain Mapping, 36(8): 3047-3063. DOI: 10.1002/hbm.22827.
  96. Ibanez, A., Garcia, A.M., Esteves, S., Yoris, A., Munoz, E., Reynaldo, L., … Manes, F. (2018). Social neuroscience: undoing the schism between neurology and psychiatry. [Review Research Support, Non-U.S. Gov’t]. Society for Neuroscience, 13(1): 1-39. DOI: 10.1080/17470919.2016.1245214.
  97. Inagaki, T.K., Ray, L.A., Irwin, M.R., Way, B.M. & Eisenberger, N.I. (2016). Opioids and social bonding: naltrexone reduces feelings of social connection. Social Cognitive and Affective Neuroscience, 11(5): 728-735. DOI: 10.1093/scan/nsw006.
  98. Inoue, Y., Yamada, K. & Kanba, S. (2006). Deficit in theory of mind is a risk for relapse of major depression. Journal of Affective Disorders, 95(1-3): 125-127. DOI: 10.1016/j.jad.2006.04.018.
  99. Insel, T.R. (2010). The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. [Review]. Neuron, 65(6): 768-779. DOI: 10.1016/j.neuron.2010.03.005.
  100. Jensen, J.H., Knorr, U., Vinberg, M., Kessing, L.V. & Miskowiak, K.W. (2016). Discrete neurocognitive subgroups in fully or partially remitted bipolar disorder: Associations with functional abilities. Journal of Affective Disorders, 205: 378-386. DOI: 10.1016/j.jad.2016.08.018.
  101. Job, M.O., Tang, A., Hall, F.S., Sora, I., Uhl, G.R., Bergeson, S.E. & Gonzales, R.A. (2007). Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. [Comparative Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov’t]. Biological Psychiatry, 62(6): 627-634. DOI: 10.1016/j.biopsych.2006.11.016.
  102. Jobst, A., Sabass, L., Palagyi, A., Bauriedl-Schmidt, C., Mauer, M.C., Sarubin, N., … Padberg, F. (2015). Effects of social exclusion on emotions and oxytocin and cortisol levels in patients with chronic depression. [Research Support, Non-U.S. Gov’t]. Journal of Psychiatric Research, 60: 170-177. DOI: 10.1016/j.jpsychires.2014.11.001.
  103. Johnson, K.V. & Dunbar, R.I. (2016). Pain tolerance predicts human social network size. Scientific Reports, 6: 25267. DOI: 10.1038/srep25267.
  104. Kalbe, E., Schlegel, M., Sack, A.T., Nowak, D.A., Dafotakis, M., Bangard, C., … Kessler, J. (2010). Dissociating cognitive from affective theory of mind: a TMS study. [Research Support, Non-U.S. Gov’t]. Cortex, 46(6): 769-780. DOI: 10.1016/j.cortex.2009.07.010.
  105. Kaldewaij, R., Koch, S.B., Volman, I., Toni, I. & Roelofs, K. (2017). On the Control of Social Approach-Avoidance Behavior: Neural and Endocrine Mechanisms. [Review]. Current Topics in Behavioral Neurosciences, 30: 275-293. DOI: 10.1007/7854_2016_446.
  106. Kamilar-Britt, P. & Bedi, G. (2015). The prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA): Controlled studies in humans and laboratory animals. [Research Support, N.I.H., Extramural Review]. Neuroscience & Biobehavioral Reviews, 57: 433-446. DOI: 10.1016/j.neubiorev.2015.08.016.
  107. Kennedy, D.P. & Adolphs, R. (2012). The social brain in psychiatric and neurological disorders. [Research Support, N.I.H., Extramural Review]. Trends in Cognitive Sciences, 16(11): 559-572. DOI: 10.1016/j.tics.2012.09.006.
  108. Kerestes, R., Chase, H.W., Phillips, M.L., Ladouceur, C.D. & Eickhoff, S.B. (2017). Multimodal evaluation of the amygdala’s functional connectivity. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Neuroimage, 148: 219-229. DOI: 10.1016/j.neuroimage.2016.12.023.
  109. Klauke, B., Deckert, J., Reif, A., Pauli, P., Zwanzger, P., Baumann, C., … Domschke, K. (2011). Serotonin transporter gene and childhood trauma--a G x E effect on anxiety sensitivity. Depression and Anxiety, 28(12): 1048-1057. DOI: 10.1002/da.20840.
  110. Koob, G.F. & Volkow, N.D. (2016). Neurobiology of addiction: a neurocircuitry analysis. [Review]. Lancet Psychiatry, 3(8): 760-773. DOI: 10.1016/S2215-0366(16)00104-8.
  111. Koscik, T.R. & Tranel, D. (2011). The human amygdala is necessary for developing and expressing normal interpersonal trust. [Research Support, N.I.H., Extramural]. Neuropsychologia, 49(4): 602-611. DOI: 10.1016/j.neuropsychologia.2010.09.023.
  112. Krajbich, I., Adolphs, R., Tranel, D., Denburg, N.L. & Camerer, C.F. (2009). Economic games quantify diminished sense of guilt in patients with damage to the prefrontal cortex. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, Non-P.H.S.]. Journal of Neuroscience, 29(7): 2188-2192. DOI: 10.1523/JNEUROSCI.5086-08.2009.
  113. Kupferberg, A., Bicks, L. & Hasler, G. (2016). Social functioning in major depressive disorder. [Review]. Neuroscience & Biobehavioral Reviews, 69: 313-332. DOI: 10.1016/j.neubiorev.2016.07.002.
  114. Kupferberg, A., Hager, O.M., Fischbacher, U., Brandle, L.S., Haynes, M. & Hasler, G. (2016). Testing the social competition hypothesis of depression using a simple economic game. BJPsych Open, 2(2): 163-169. DOI: 10.1192/bjpo.bp.115.001362.
  115. Laurent, H.K. & Ablow, J.C. (2012). A cry in the dark: depressed mothers show reduced neural activation to their own infant’s cry. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, Non-P.H.S.]. Social Cognitive and Affective Neuroscience, 7(2): 125-134. DOI: 10.1093/scan/nsq091.
  116. Lebow, M.A. & Chen, A. (2016). Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders. [Research Support, Non-U.S. Gov’t]. Molecular Psychiatry, 21(4): 450-463. DOI: 10.1038/mp.2016.1.
  117. Lehmann, M.L., Brachman, R.A., Martinowich, K., Schloesser, R.J. & Herkenham, M. (2013). Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis. [Research Support, N.I.H., Intramural]. Journal of Neuroscience, 33(7): 2961-2972. DOI: 10.1523/JNEUROSCI.3878-12.2013.
  118. Leong, J.K., Pestilli, F., Wu, C.C., Samanez-Larkin, G.R. & Knutson, B. (2016). White-Matter Tract Connecting Anterior Insula to Nucleus Accumbens Correlates with Reduced Preference for Positively Skewed Gambles. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Neuron, 89(1): 63-69. DOI: 10.1016/j.neuron.2015.12.015.
  119. Li, T.M. & Wong, P.W. (2015). Youth social withdrawal behavior (hikikomori): A systematic review of qualitative and quantitative studies. [Review]. Australian and New Zealand Journal of Psychiatry, 49(7): 595-609. DOI: 10.1177/0004867415581179.
  120. Lieberman, M.D. (2007). Social cognitive neuroscience: a review of core processes. [Research Support, N.I.H., Extramural]. Annual Review of Psychology, 58: 259-289. DOI: 10.1146/annurev.psych.58.110405.085654.
  121. Liu, R.T., Kraines, M.A., Massing-Schaffer, M. & Alloy, L.B. (2014). Rejection sensitivity and depression: mediation by stress generation. Psychiatry, 77(1): 86-97. DOI: 10.1521/psyc.2014.77.1.86.
  122. Lopez, N.L., Vazquez, D.M. & Olson, S.L. (2004). An integrative approach to the neurophysiological substrates of social withdrawal and aggression. [Research Support, U.S. Gov’t, P.H.S.]. Development and Psychopathology, 16(1): 69-93.
  123. Luo, M., Li, Y. & Zhong, W. (2016). Do dorsal raphe 5-HT neurons encode “beneficialness”? [Review]. Neurobiology of Learning and Memory, 135: 40-49. DOI: 10.1016/j.nlm.2016.08.008.
  124. Ma, Y., Shamay-Tsoory, S., Han, S. & Zink, C.F. (2016). Oxytocin and Social Adaptation: Insights from Neuroimaging Studies of Healthy and Clinical Populations. [Research Support, Non-U.S. Gov’t Review]. Trends in Cognitive Sciences, 20(2): 133-145. DOI: 10.1016/j.tics.2015.10.009.
  125. Macoveanu, J. (2014). Serotonergic modulation of reward and punishment: evidence from pharmacological fMRI studies. [Research Support, Non-U.S. Gov’t Review]. Brain Research, 1556: 19-27. DOI: 10.1016/j.brainres.2014.02.003.
  126. MacQueen, G.M., Young, L.T. & Joffe, R.T. (2001). A review of psychosocial outcome in patients with bipolar disorder. [Research Support, Non-U.S. Gov’t Review]. Acta Psychiatrica Scandinavica, 103(3): 163-170. DOI: 10.1034/j.1600-0447.2001.00059.x.
  127. MacQueen, G.M., Young, L.T., Robb, J.C., Marriott, M., Cooke, R.G. & Joffe, R.T. (2000). Effect of number of episodes on wellbeing and functioning of patients with bipolar disorder. [Research Support, Non-U.S. Gov’t]. Acta Psychiatrica Scandinavica, 101(5): 374-381. DOI: 10.1034/j.1600-0447.2000.101005374.x.
  128. Marlin, B.J., Mitre, M., D’Amour J.A., Chao, M.V. & Froemke, R.C. (2015). Oxytocin enables maternal behaviour by balancing cortical inhibition. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Nature, 520(7548): 499-504. DOI: 10.1038/nature14402.
  129. Masten, C.L., Eisenberger, N.I., Borofsky, L.A., Pfeifer, J.H., McNealy, K., Mazziotta, J.C. & Dapretto, M. (2009). Neural correlates of social exclusion during adolescence: understanding the distress of peer rejection. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, Non-P.H.S.]. Social Cognitive and Affective Neuroscience, 4(2): 143-157. DOI: 10.1093/scan/nsp007.
  130. McIntyre, R.S., Berk, M., Brietzke, E., Goldstein, B.I., Lopez-Jaramillo, C., Kessing, L.V., … Mansur, R.B. (2020). Bipolar disorders. [Research Support, Non-U.S. Gov’t Review]. Lancet, 396(10265): 1841-1856. DOI: 10.1016/S0140-6736(20)31544-0.
  131. Menon, V. (2011). Large-scale brain networks and psychopathology: a unifying triple network model. [Review]. Trends in Cognitive Sciences, 15(10): 483-506. DOI: 10.1016/j.tics.2011.08.003.
  132. Monk, C.S., Telzer, E.H., Mogg, K., Bradley, B.P., Mai, X., Louro, H.M., … Pine, D.S. (2008). Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. [Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov’t]. Archives of General Psychiatry, 65(5): 568-576. DOI: 10.1001/archpsyc.65.5.568.
  133. Morawetz, C., Kellermann, T., Kogler, L., Radke, S., Blechert, J. & Derntl, B. (2016). Intrinsic functional connectivity underlying successful emotion regulation of angry faces. Social Cognitive and Affective Neuroscience, 11(12): 1980-1991. DOI: 10.1093/scan/nsw107.
  134. Naranjo, C., Kornreich, C., Campanella, S., Noel, X., Vandriette, Y., Gillain, B., … Constant, E. (2011). Major depression is associated with impaired processing of emotion in music as well as in facial and vocal stimuli. [Research Support, Non-U.S. Gov’t]. Journal of Affective Disorders, 128(3): 243-251. DOI: 10.1016/j.jad.2010.06.039.
  135. Nummenmaa, L., Manninen, S., Tuominen, L., Hirvonen, J., Kalliokoski, K.K., Nuutila, P., … Sams, M. (2015). Adult attachment style is associated with cerebral mu-opioid receptor availability in humans. [Research Support, Non-U.S. Gov’t]. Human Brain Mapping, 36(9): 3621-3628. DOI: 10.1002/hbm.22866.
  136. Nusslock, R. & Alloy, L.B. (2017). Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective. [Review]. Journal of Affective Disorders. DOI: 10.1016/j.jad.2017.02.001.
  137. O’Connell, L.A. & Hofmann, H.A. (2011). Genes, hormones, and circuits: an integrative approach to study the evolution of social behavior. [Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, Non-P.H.S. Review]. Frontiers in Neuroendocrinology, 32(3): 320-335. DOI: 10.1016/j.yfrne.2010.12.004.
  138. O’Toole, M.S., Hougaard, E. & Mennin, D.S. (2013). Social anxiety and emotion knowledge: a meta-analysis. [Meta-Analysis]. Journal of Anxiety Disorders, 27(1): 98-108. DOI: 10.1016/j.janxdis.2012.09.005.
  139. Pincus, D., Kose, S., Arana, A., Johnson, K., Morgan, P.S., Borckardt, J., … Nahas, Z. (2010). Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study. Frontiers in Psychiatry, 1: 134. DOI: 10.3389/fpsyt.2010.00134.
  140. Pitcher, D., Walsh, V. & Duchaine, B. (2011). The role of the occipital face area in the cortical face perception network. [Research Support, Non-U.S. Gov’t Review]. Experimental Brain Research, 209(4): 481-493. DOI: 10.1007/s00221-011-2579-1.
  141. Plana, I., Lavoie, M.A., Battaglia, M. & Achim, A.M. (2014). A meta-analysis and scoping review of social cognition performance in social phobia, posttraumatic stress disorder and other anxiety disorders. [Meta-Analysis Research Support, Non-U.S. Gov’t Review]. Journal of Anxiety Disorders, 28(2): 169-177. DOI: 10.1016/j.janxdis.2013.09.005.
  142. Porcelli, S., Van Der Wee, N., van der Werff, S., Aghajani, M., Glennon, J.C., van Heukelum, S., … Serretti, A. (2019). Social brain, social dysfunction and social withdrawal. [Research Support, Non-U.S. Gov’t Review]. Neuroscience & Biobehavioral Reviews, 97: 10-33. DOI: 10.1016/j.neubiorev.2018.09.012.
  143. Proulx, C.D., Hikosaka, O. & Malinow, R. (2014). Reward processing by the lateral habenula in normal and depressive behaviors. [Review]. Nature Neuroscience, 17(9): 1146-1152. DOI: 10.1038/nn.3779.
  144. Reddy, L. & Kanwisher, N. (2007). Category selectivity in the ventral visual pathway confers robustness to clutter and diverted attention. [Research Support, N.I.H., Extramural]. Current Biology, 17(23): 2067-2072. DOI: 10.1016/j.cub.2007.10.043.
  145. Rizzolatti, G. & Craighero, L. (2004). The mirror-neuron system. [Research Support, Non-U.S. Gov’t Review]. Annual Review of Neuroscience, 27: 169-192. DOI: 10.1146/annurev.neuro.27.070203.144230.
  146. Rizzolatti, G. & Sinigaglia, C. (2016). The mirror mechanism: a basic principle of brain function. [Review]. Nature Reviews Neuroscience, 17(12): 757-765. DOI: 10.1038/nrn.2016.135.
  147. Robinson, O.J., Overstreet, C., Allen, P.S., Letkiewicz, A., Vytal, K., Pine, D.S. & Grillon, C. (2013). The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal-amygdala ‘aversive amplification’ circuit. [Randomized Controlled Trial Research Support, N.I.H., Intramural]. Neuroimage, 78: 217-223. DOI: 10.1016/j.neuroimage.2013.03.075.
  148. Saygin, Z.M., Osher, D.E., Augustinack, J., Fischl, B. & Gabrieli, J.D. (2011). Connectivity-based segmentation of human amygdala nuclei using probabilistic tractography. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Neuroimage, 56(3): 1353-1361. DOI: 10.1016/j.neuroimage.2011.03.006.
  149. Schurz, M., Radua, J., Aichhorn, M., Richlan, F. & Perner, J. (2014). Fractionating theory of mind: a meta-analysis of functional brain imaging studies. [Meta-Analysis Review]. Neuroscience & Biobehavioral Reviews, 42: 9-34. DOI: 10.1016/j.neubiorev.2014.01.009.
  150. Scott-Van Zeeland, A.A., Dapretto, M., Ghahremani, D.G., Poldrack, R.A. & Bookheimer, S.Y. (2010). Reward processing in autism. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Autism Research, 3(2): 53-67. DOI: 10.1002/aur.122.
  151. Seeley, W.W., Menon, V., Schatzberg, A.F., Keller, J., Glover, G.H., Kenna, H., … Greicius, M.D. (2007). Dissociable intrinsic connectivity networks for salience processing and executive control. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, Non-P.H.S.]. Journal of Neuroscience, 27(9): 2349-2356. DOI: 10.1523/JNEUROSCI.5587-06.2007.
  152. Seiglie, M.P., Smith, K.L., Blasio, A., Cottone, P. & Sabino, V. (2015). Pituitary adenylate cyclase-activating polypeptide induces a depressive-like phenotype in rats. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Psychopharmacology (Berl), 232(20): 3821-3831. DOI: 10.1007/s00213-015-4045-4.
  153. Semendeferi, K., Lu, A., Schenker, N. & Damasio, H. (2002). Humans and great apes share a large frontal cortex. Nature Neuroscience, 5(3): 272-276. DOI: 10.1038/nn814.
  154. Shahrestani, S., Kemp, A.H. & Guastella, A.J. (2013). The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis. [Meta-Analysis Research Support, Non-U.S. Gov’t Review]. Neuropsychopharmacology, 38(10): 1929-1936. DOI: 10.1038/npp.2013.86.
  155. Shamay-Tsoory, S.G. & Abu-Akel, A. (2016). The Social Salience Hypothesis of Oxytocin. [Review]. Biological Psychiatry, 79(3): 194-202. DOI: 10.1016/j.biopsych.2015.07.020.
  156. Shamay-Tsoory, S.G., Tomer, R., Berger, B.D. & Aharon-Peretz, J. (2003). Characterization of empathy deficits following prefrontal brain damage: the role of the right ventromedial prefrontal cortex. [Research Support, Non-U.S. Gov’t]. Journal of Cognitive Neuroscience, 15(3): 324-337. DOI: 10.1162/089892903321593063.
  157. Sharma, S., Powers, A., Bradley, B. & Ressler, K.J. (2016). Gene x Environment Determinants of Stress- and Anxiety-Related Disorders. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Review]. Annual Review of Psychology, 67: 239-261. DOI: 10.1146/annurev-psych-122414-033408.
  158. Skuse, D.H. & Gallagher, L. (2009). Dopaminergic-neuropeptide interactions in the social brain. [Research Support, Non-U.S. Gov’t Review]. Trends in Cognitive Sciences, 13(1): 27-35. DOI: 10.1016/j.tics.2008.09.007.
  159. Sole, B., Bonnin, C.M., Jimenez, E., Torrent, C., Torres, I., Varo, C., … Reinares, M. (2018). Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster-analytic approach. [Research Support, Non-U.S. Gov’t]. Acta Psychiatrica Scandinavica, 137(6): 516-527. DOI: 10.1111/acps.12871.
  160. Sollberger, M., Stanley, C.M., Wilson, S.M., Gyurak, A., Beckman, V., Growdon, M., … Rankin, K.P. (2009). Neural basis of interpersonal traits in neurodegenerative diseases. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Neuropsychologia, 47(13): 2812-2827. DOI: 10.1016/j.neuropsychologia.2009.06.006.
  161. Spence, S.H. & Rapee, R.M. (2016). The etiology of social anxiety disorder: An evidence-based model. [Review]. Behaviour Research and Therapy, 86: 50-67. DOI: 10.1016/j.brat.2016.06.007.
  162. Spunt, R.P., Satpute, A.B. & Lieberman, M.D. (2011). Identifying the what, why, and how of an observed action: an fMRI study of mentalizing and mechanizing during action observation. [Research Support, Non-U.S. Gov’t]. Journal of Cognitive Neuroscience, 23(1): 63-74. DOI: 10.1162/jocn.2010.21446.
  163. Stein, M.B. & Stein, D.J. (2008). Social anxiety disorder. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t Review]. Lancet, 371(9618): 1115-1125. DOI: 10.1016/S0140-6736(08)60488-2.
  164. Stuhrmann, A., Suslow, T. & Dannlowski, U. (2011). Facial emotion processing in major depression: a systematic review of neuroimaging findings. Biology of Mood & Anxiety Disorders, 1(1): 10. DOI: 10.1186/2045-5380-1-10.
  165. Surguladze, S.A., Marshall, N., Schulze, K., Hall, M.H., Walshe, M., Bramon, E., … McDonald, C. (2010). Exaggerated neural response to emotional faces in patients with bipolar disorder and their first-degree relatives. [Research Support, Non-U.S. Gov’t]. Neuroimage, 53(1): 58-64. DOI: 10.1016/j.neuroimage.2010.05.069.
  166. Svob Strac, D., Pivac, N. & Muck-Seler, D. (2016). The serotonergic system and cognitive function. [Review]. Translational Neuroscience, 7(1): 35-49. DOI: 10.1515/tnsci-2016-0007.
  167. Tabak, B.A., Meyer, M.L., Dutcher, J.M., Castle, E., Irwin, M.R., Lieberman, M.D. & Eisenberger, N.I. (2016). Oxytocin, but not vasopressin, impairs social cognitive ability among individuals with higher levels of social anxiety: a randomized controlled trial. [Randomized Controlled Trial]. Social Cognitive and Affective Neuroscience, 11(8): 1272-1279. DOI: 10.1093/scan/nsw041.
  168. Takahashi, H., Takano, H., Camerer, C.F., Ideno, T., Okubo, S., Matsui, H., … Suhara, T. (2012). Honesty mediates the relationship between serotonin and reaction to unfairness. [Research Support, Non-U.S. Gov’t]. PNAS, 109(11): 4281-4284. DOI: 10.1073/pnas.1118687109.
  169. Tesli, M., Kauppi, K., Bettella, F., Brandt, C.L., Kaufmann, T., Espeseth, T., … Andreassen, O.A. (2015). Altered Brain Activation during Emotional Face Processing in Relation to Both Diagnosis and Polygenic Risk of Bipolar Disorder. [Research Support, Non-U.S. Gov’t]. PLoS One, 10(7): e0134202. DOI: 10.1371/journal.pone.0134202.
  170. Tremeau, F., Antonius, D., Malaspina, D., Goff, D.C. & Javitt, D.C. (2016). Loneliness in schizophrenia and its possible correlates. An exploratory study. Psychiatry Research, 246, 211-217. DOI: 10.1016/j.psychres.2016.09.043.
  171. Turchi, F., Amodeo, G., Favaretto, E., Righini, S., Mellina, E., La Mela, C. & Fagiolini, A. (2016). [Neural basis of social cognition in bipolar disorder]. [Review]. Rivista di Psichiatria, 51(5): 177-189. DOI: 10.1708/2476.25886.
  172. van Neerven, T., Bos, D.J. & van Haren, N.E. (2021). Deficiencies in Theory of Mind in patients with schizophrenia, bipolar disorder, and major depressive disorder: A systematic review of secondary literature. [Review Systematic Review]. Neuroscience & Biobehavioral Reviews, 120, 249-261. DOI: 10.1016/j.neubiorev.2020.11.011.
  173. Vialou, V., Bagot, R.C., Cahill, M.E., Ferguson, D., Robison, A.J., Dietz, D.M., … Nestler, E.J. (2014). Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of DeltaFosB. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Journal of Neuroscience, 34(11): 3878-3887. DOI: 10.1523/JNEUROSCI.1787-13.2014.
  174. Wang, J., Qin, W., Liu, B., Zhou, Y., Wang, D., Zhang, Y., … Yu, C. (2014). Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament. [Research Support, Non-U.S. Gov’t]. Brain Structure and Function, 219(5): 1543-1554. DOI: 10.1007/s00429-013-0584-9.
  175. Wang, X., Song, Y., Zhen, Z. & Liu, J. (2016). Functional integration of the posterior superior temporal sulcus correlates with facial expression recognition. [Research Support, Non-U.S. Gov’t]. Human Brain Mapping, 37(5): 1930-1940. DOI: 10.1002/hbm.23145.
  176. Winter, J. & Jurek, B. (2019). The interplay between oxytocin and the CRF system: regulation of the stress response. [Review]. Cell and Tissue Research, 375(1): 85-91. DOI: 10.1007/s00441-018-2866-2.
  177. Wolkenstein, L., Schonenberg, M., Schirm, E. & Hautzinger, M. (2011). I can see what you feel, but I can’t deal with it: Impaired theory of mind in depression. Journal of Affective Disorders, 132(1-2): 104-111. DOI: 10.1016/j.jad.2011.02.010.
  178. Wook Koo, J., Labonte, B., Engmann, O., Calipari, E.S., Juarez, B., Lorsch, Z., … Nestler, E.J. (2016). Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors. Biological Psychiatry, 80(6): 469-478. DOI: 10.1016/j.biopsych.2015.12.009.
  179. Wu, X., Wu, J., Xia, S., Li, B. & Dong, J. (2013). Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice. [Research Support, Non-U.S. Gov’t]. Behavioural Brain Research, 256: 602-608. DOI: 10.1016/j.bbr.2013.09.034.
  180. Yager, L.M., Garcia, A.F., Wunsch, A.M. & Ferguson, S.M. (2015). The ins and outs of the striatum: role in drug addiction. [Research Support, N.I.H., Extramural Review]. Neuroscience, 301: 529-541. DOI: 10.1016/j.neuroscience.2015.06.033.
  181. Yeo, B.T., Krienen, F.M., Sepulcre, J., Sabuncu, M.R., Lashkari, D., Hollinshead, M., … Buckner, R.L. (2011). The organization of the human cerebral cortex estimated by intrinsic functional connectivity. [Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Journal of Neurophysiology, 106(3): 1125-1165. DOI: 10.1152/jn.00338.2011.
  182. Zaki, J., Hennigan, K., Weber, J. & Ochsner, K.N. (2010). Social cognitive conflict resolution: contributions of domain-general and domain-specific neural systems. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t]. Journal of Neuroscience, 30(25): 8481-8488. DOI: 10.1523/JNEUROSCI.0382-10.2010.
  183. Zhong, B.L., Chen, S.L., Tu, X. & Conwell, Y. (2017). Loneliness and Cognitive Function in Older Adults: Findings From the Chinese Longitudinal Healthy Longevity Survey. Journals of Gerontology – Series B Psychological Sciences and Social Sciences, 72(1): 120-128. DOI: 10.1093/geronb/gbw037.

Metriche

Caricamento metriche ...