Patients with pathological narcissism experience guilt and implement specific coping strategies to manage emotion. The strategies most commonly found in functioning in narcissistic personality disorder are atonement, externalization of anger on others and the renunciation of pursuing one’s own desires, supported by the blocking of action. In this paper, we first describe the different types of guilt, in particular deontological and altruistic and then, under the lenses of Metacognitive Interpersonal Therapy, we describe the interactions between guilt, narcissistic functioning and interpersonal maladaptive schemas. These schemas guide patients from negative, rigid and embodied representations of himself and others. We provide the description of a clinical case of a man with narcissistic personality disorder (NPD and show how assessing the role of guilt in his functioning helped reducing guilt and how this was beneficial in treating narcissism.