Obsessive Compulsive Disorder (OCD) is a debilitating condition that tends to be chronic. To date, a multiplicity of interventions aiming to treat this disorder exists. The vastness of literature and the difficulty for the clinician to orientate within this context drove several institutions to develop guidelines related to the treatment of OCD. Despite the aim of these guidelines is not to establish clinical standard for professional practice, these provide precious material that aim to take informed decisions. In this contribution, we offer a summary of the guidelines developed by the National Institute for Health and Clinical Excellence and by the American Psychiatric Association as well as a brief overview of their development process. Then, a selection of some relevant contributions is summed up – systematic reviews
and meta-analyses – that sometimes supported the process of formulation of recommendations contained in the illustrated guidelines.