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Parenthood: The Keystone. The Parental Brain, Development, and Salutogenesis Parental Functioning as the Conductor of Adult Health Outcomes

  • Rossana Terni
DOI
https://doi.org/10.3280/pnei2025oa23570
Submitted
agosto 27, 2026
Published
2026-09-30

Abstract

The transition to parenthood has undergone a radical structural and conceptual evolution in recent decades, driven by unprecedented demographic shifts and rapidly changing family paradigms. These societal changes are profoundly reshaping the psychological and clinical framework of parenthood. Concurrently, discoveries in cognitive neuroscience and psychoneuroendocrinoimmunology (PNEI) have revealed that this transition represents a unique biological window, characterized by extraordinary adult neuroplasticity and epigenetic vulnerability. Neuroimaging studies confirm that entering parenthood triggers extensive anatomical remodeling in both biological and non-biological (or non-gestational) parents.

However, this heightened neuroplasticity also renders the parental brain highly vulnerable to environmental and psychosocial stressors. Untreated parental distress compromises interactional synchrony and introduces severe transgenerational risks, predicting an increased susceptibility to emotional, behavioral, and even psychotic symptoms in the adult offspring. Furthermore, under the weight of modern socioeconomic pressures and unmitigated stress, parents face the risk of parental burnout.

Therefore, building a robust culture of health and well-being that is both equitable and sustainable requires an intersectoral and multidimensional framework where governmental institutions, healthcare systems, commercial enterprises, local communities, and individual citizens share a collective responsibility.

References

  1. Abraham E., & Feldman R. (2022). The neural basis of human fatherhood: a unique biocultural perspective on plasticity of brain and behavior. Clin Child Fam Psychol Rev., 25(1), 93–109. Doi: 10.1007/s10567 022 00381 9
  2. Álvarez García P., García Fernández R., Martín Vázquez C., Calvo Ayuso N., & Quiroga Sánchez E. (2024). Postpartum Depression in Fathers: A Systematic Review. J. Clin. Med., 13, 2949. Doi: 10.3390/jcm13102949
  3. Athan A.M. (2024). A critical need for the concept of matrescence in perinatal psychiatry. Frontiers in Psychiatry, 15, 1364845. Doi: 10.3389/fpsyt.2024.1364845
  4. Azhari A., Leck WQ., Gabrieli G. et al. (2019). Parenting stress undermines mother child brain to brain synchrony: a hyperscanning study. Sci Rep., 9(1), 11407. Doi: 10.1038/s41598 019 47810 4, 2019/8/6
  5. Bogdán P.M., Varga K., Tóth L., Gróf K., & Pakai A. (2025). Parental Burnout: A Progressive Condition Potentially Compromising Family Well Being–A Narrative Review. Healthcare, 13, 1603. Doi: 10.3390/healthcare13131603
  6. Carbonella S., & Gandini V. (2023). Diventare genitori è un’esperienza Pnei. PneiReview, 2, 7 20. Doi: 10.3280/PNEI2023 002002
  7. Carmona S. et al. (2019). Pregnancy and adolescence entail similar neuroanatomical adaptations: a comparative analysis of cerebral morphometric changes. Hum. Brain Mapp., 40, 2143–2152. Doi: 10.1002/hbm.24513
  8. Carmona S., & Vilarroya O. (2025). The transition to parenthood: Linking hormones, brain, and behav ior. Psychoneuroendocrinology, 172, 107247. Doi: 10.1016/j.psyneuen.2024.107247
  9. Cermakova P., Chlapečka A., Csajbók Z., Andrýsková L., Brázdil M., & Marečková K. (2023). Parental education, cognition and functional connectivity of the salience network. Scientific Reports, 13(1), 2761. Doi: 10.1038/s41598 023 29508 w
  10. Chechko N. et al. (2023). Neural responses to monetary incentives in postpartum women affected by baby blues. Psychoneuroendocrinology 148, 105991. Doi: 10.1016/j.psyneuen.2022.105991
  11. CSDH (2008). Closing the Gap in a Generation: Health Equity Through Action on the Social Determi nants of Health. Final Report of the Commission on Social Determinants of Health. Geneva: World Health Organization.
  12. Davey C.G., Pujol J., & Harrison B.J. (2016). Mapping the self in the brain’s default mode network.Neuroimage, 132, 390–397. Doi: 10.1016/j.neuroimage.2016.02.022
  13. De Bari M., & Terni R. (2023). Dalla struttura alla funzione familiare: i ruoli materno e paterno nelle famiglie “moderne”. PneiReview, 2, 21 34. Doi: 10.3280/PNEI2023 002003
  14. Feibel A., Pham H., Glover V., O’Connor T.G., & O’Donnell K.J. (2026). Timing of Exposure to Parental Depression from Pregnancy to Young Adulthood and Mental Health in Adult Offspring. JAMA Network Open, 9(4), e264892. Doi: 10.1001/jamanetworkopen.2026.4892
  15. Feldman R. (2015). The adaptive human parental brain: implications for children’s social development. Trends Neurosci., 38, 387–399. Doi: 10.1016/j.tins.2015.04.004
  16. Haj Yahia M.M., Sokar S., Hassan Abbas N., & Malka M. (2019). The relationship between exposure to family violence in childhood and post traumatic stress symptoms in young adulthood: The mediating role of social support. Child Abus. Negl., 92, 126–138. Doi: 10.1016/j.chiabu.2019.03.023
  17. Herrero Roldán S., & Martín Rodríguez A. (2025). Neglect and Neurodevelopment: A Narrative Re view Understanding the Link Between Child Neglect and Executive Function Deficits. Biomedicines, 13, 1565. Doi: 10.3390/biomedicines13071565
  18. Hoekzema E., van Steenbergen H., Straathof M. et al. (2022). Mapping the effects of pregnancy on rest ing state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture. Nat Commun., 13(1), 6931. Doi: 10.1038/s41467 022 33884 8, 2022/11/22
  19. Hosokawa R., & Katsura T. (2024). Association Between Parents’ Perceived Social Support and Chil dren’s Psychological Adjustment: A Cross Sectional Study. BMC Pediatr, 24, 756. DOI: Doi: 10.1186/s12887 024 05235 7
  20. Kim P., Rigo P., Mayes LC., Feldman R., Leckman J.F., & Swain J.E. (2014). Neural plasticity in fathers of human infants. Soc Neurosci., 9(5), 522–535. Doi: 10.1080/17470919.2014.933713
  21. Laurent H.K., Stevens A., & Ablow J.C. (2011). Neural correlates of hypothalamic pituitaryadrenal regulation of mothers with their infants. BiolPsychiatry, 70(9), 826–832. Doi: 10.1016/j.biopsych.2011.06.011
  22. Livingston G. (2018). They’re waiting longer, but U.S. women today more likely to have children than a decade ago. Pew Research Center. https://www. pewresearch.org/social trends/2018/01/18/theyre waiting longer but u swomen today more likely to have children than a decade ago/.
  23. Martinez Garcia M., Paternina Die M., Cardenas S.I. et al. (2023). First time fathers show longitudinal gray matter cortical volume reductions: evidence from two international samples. Cereb Cortex, 33(7), 4156–4163. Doi: 10.1093/cercor/bhac333
  24. Mikolajczak M., & Roskam I. (2018). A Theoretical and Clinical Framework for Parental Burnout: The Bal ance Between Risks and Resources (BR2). Front. Psychol., 9, 886. Doi: 10.3389/fpsyg.2018.00886
  25. Morgan J.K. et al. (2017). Postpartum depressive symptoms moderate the link between mothers’ neural response to positive faces in reward and social regions and observed caregiving. Soc. Cogn. Affect. Neurosci. 12, 1605–1613. Doi: 10.1093/scan/nsx087
  26. Nguyen T., Schleihauf H., Kungl M., Kayhan E., Hoehl S., & Vrticka P. (2021). Interpersonal neural synchrony during father child problem solving: an fNIRS hyperscanning study. Child Dev. 92(4), e565–e580. Doi: 10.1111/cdev.13510
  27. Paternina Die M., Martinez Garcia M., Martin de Blas D. et al. (2024). Women’s neuroplasticity during ges tation, childbirth and postpartum. NatNeurosci., 27(2), 319–327. Doi: 10.1038/s41593 023 01513 2
  28. Pawluski J.L. (2024). The parental brain, perinatal mental illness, and treatment: A review of key structural and functional changes. Seminars in Perinatology, 48, 151951. Doi: 10.1016/j.semperi.2024.15195
  29. Pawluski J.L., Lonstein J.S., & Fleming A.S. (2017). The neurobiology of postpartum anxiety and depression. Trends Neurosci., 40(2), 106–120. Doi: 10.1016/j.tins.2016.11.009
  30. Raphael D. (1975). Matrescence, becoming a mother, a “new/old” rite de passage. In Raphael D. (Ed.), Being female: Reproduction, power, and change (pp. 65–71). Berlin: De Gruyter Mouton.
  31. Roskam I., & Mikolajczak M. (2021). The slippery slope of parental exhaustion: A process model of parental burnout. J. Appl. Dev. Psychol., 77, 101354. Doi: 10.1016/j.appdev.2021.101354
  32. Rutherford H.J., & Mayes, L.C. (2019). Parenting stress: A novel mechanism of addiction vulnerability. Neurobiol Stress, 11, 100172. Doi: 10.1016/j.ynstr.2019.100172
  33. Schimmelpfennig J., Topczewski J., Zajkowski W., & Jankowiak Siuda K. (2023). The role of the sali ence network in cognitive and affective deficits. Frontiers in human neuroscience, 17, 1133367. Doi: 10.3389/fnhum.2023.1133367
  34. Seeley W.W. (2019). The Salience Network: A Neural System for Perceiving and Responding to Homeostatic Demands. Journal of Neuroscience, 39(50), 9878–9882. Doi: 10.1523/JNEUROSCI.1138 17.2019
  35. Servin Barthet C., Martínez García M., Pretus C., Paternina Die M., Soler A., Khymenets O., Pozo O.J.,Leuner B., Vilarroya O., & Carmona S. (2023). The transition to motherhood: linking hormones, brain and behaviour. Nat. Rev. Neurosci., 24(10), 605–619. Doi: 10.1038/s41583 023 00733 6
  36. Stein A., Pearson R.M., Goodman S.H. et al. (2014). Effects of perinatal mental disorders on the fetus and child. Lancet, 384(9956), 1800–1819. Doi: 10.1016/S0140 6736(14)61277 0
  37. Stoll B.J. et al. (2004). Neurodevelopmental and growth impairment among extremely low birth weight infants with neonatal infection. JAMA, 292, 2357–2365. Doi: 10.1001/jama.292.19.2357
  38. Straathof M., Halmans S., Pouwels P.J.W., Crone E.A., & Hoekzema E. (2026). The effects of a second pregnancy on women’s brain structure and function. Nature Communications, 17, 1495. Doi: 10.1038/s41467 026 69370 8
  39. Tziraki Segal et al. (2019). Creating a Culture of Health in Planning and Implementing Innovative Strategies Addressing Non communicable Chronic Diseases. Front. Sociol., 4, 9. DOI: Doi: 10.3389/fsoc.2019.00009
  40. Venuti P., Simonelli A., & Rigo P. (2018). Basi biologiche della funzione genitoriale. Milano: Raffaello Cortina.
  41. Wenzel E.S., Frye R., Roberson Nay R., & Payne J.L. (2025). The neurobiology of postpartum depres sion. Trends in Neurosciences, 48, 7. Doi: 10.1016/j.tins.2025.05.005
  42. Worska A., Jóźwiak B., Ciązyńska J., Maciaszek J., & Laudańska Krzemińska I. (2026). The pregnant brain: A narrative review of neuroplasticity and adaptation for motherhood. Behavioural Brain Re search, 506, 116133. Doi: 10.1016/j.bbr.2026.116133