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Psyche and Life: Allostasis between the Predictive brain-mind system and Traditional Chinese Medicine

DOI
https://doi.org/10.3280/pnei2025oa19336
Inviata
febbraio 4, 2025
Pubblicato
25-02-2025

Abstract

The paradigm of allostasis and Traditional Chinese Medicine (TCM) share foundational conceptual and pathophysiological principles, as well as a holistic perspective on the relationships between psychological and biological dimensions. TCM emphasizes the profound connection between the body and Qi, while the allostatic model places the representation and regulation of bodily states at the core of all mental processes. According to predictive processing theories, the brain‐mind system employs internal models to anticipate neurosensory states, continuously comparing predictions with incoming data from external and internal environments.
By minimizing predictive errors, the brain‐mind system constructs perceptions, plans actions, and regulates allostasis. Disruptions in the balance between predictions and prediction errors can impair allostatic efficiency, leading to clinical consequences. Similarly, imbalances in Qi – stagnation, deficiency, excess – disrupt psychophysical equilibrium and contribute to the development of chronic diseases, notably under prolonged stress conditions.
Integrating Western and Eastern paradigms holds promise for developing more effective, patient‐centered therapeutic approaches.

Riferimenti bibliografici

  1. Apkarian, A.V., Baliki, M.N., & Geha, P. Y. (2009). Towards a theory of chronic pain. Progress in Neurobiology, 87(2), 81‐97. Doi: 10.1016/j.pneurobio.2008.09.018.
  2. Azzalini, D., Rebollo, I., & Tallon‐Baudry, C. (2019). Visceral Signals Shape Brain Dynamics and Cognition. Trends in Cognitive Sciences, 23, 488‐509. Doi: 10.1016/j.tics. 2019.03.007.
  3. Barsalou, L.W. (2008). Grounded cognition. Annual Review of Psychology, 59(1), 617‐645. Doi: 10.1146/annurev.psych.59.103006.093639.
  4. Bottaccioli, F. (2020). Filosofia per la medicina. Medicina per la filosofia. Oriente e Occidente a confronto. II ed. aggiornata e ampliata. Milano: Tecniche Nuove.
  5. Bottaccioli, F., & Bottaccioli, A.G. (2024a). The suggestions of ancient Chinese philosophy and medicine for contemporary scientific research, and integrative care. Brain Behavior and Immunity Integrative, 5, 100024. Doi: 10.1016/j.bbii.2023.100024.
  6. Bottaccioli, F., Bottaccioli, A.G., et al. (2024b). Antico sapere cinese e scienza contemporanea: Le suggestioni della filosofia e medicina cinese per la ricerca scientifica e la cura integrata. Independently published, www.amazon.it.
  7. Burdakov, D. (2019). Reactive and predictive homeostasis: Roles of orexin/hypocretin neurons. Neuropharmacology, 154, 61‐67. Doi: 10.1016/j.neuropharm.2018.10.024.
  8. Descartes, R. (1641). Meditations on First Philosophy. (J. Cottingham, Trans., 1986). April 2013. Cambridge University Press.
  9. Chanes, L., & Barrett, L.F. (2016). Redefining the Role of Limbic Areas in Cortical Processing. Trends Cogn Sci, 20(2): 96‐106. Doi: 10.1016/j.tics.2015.11.005.
  10. Clark, A. (2013). Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behavioral and Brain Sciences, 36(3), 181‐204. Doi: 10.1017/ S0140525X12000477.
  11. Conant, R.C., & Ashby, W.R. (1970). Every good regulator of a system must be a model of that system. International Journal of Systems Science, 1(2), 89‐97. Doi: 10.1080/ 00207727008920220.
  12. Damasio, A.R. (1996). The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philos Trans R Soc Lond B Biol Sci., 351(1346), 1413‐20. Doi: 10.1098/rstb.1996.0125.
  13. Fang, J., Jin, Z., Wang, Y., Li, K., Kong, J., Nixon, E.E., Zeng, Y., Ren, Y., Tong, H., Wang, Y., Wang, P., & Hui, K.K. (2009). The salient characteristics of the central effects of acupuncture needling: limbic‐paralimbicneocortical network modulation. Hum Brain Mapp., 30(4), 1196‐206. Doi: 10.1002/hbm.20583.
  14. Friston, K. (2010). The free‐energy principle: A unified brain theory? Nature Reviews Neuroscience, 11(2), 127‐138 Doi: 10.1038/nrn2787.
  15. Hohwy, J. (2016). The self‐evidencing brain. Noûs, 50(2), 259‐285. Doi: 10.1111/nous.12062.
  16. Huys, Q.J.M., Maia, T.V., & Frank, M.J. (2016). Computational psychiatry as a bridge from neuroscience to clinical applications. Nature Neuroscience, 19(3), 404‐413. Doi: 10.1038/nn.4238.
  17. Kanherkar, R.R., Stair, S.E., Bhatia‐Dey, N., Mills, P.J., Chopra, D., & Csoka, A.B. (2017). Epigenetic Mechanisms of Integrative Medicine. Evid Based Complement Alternat Med., 2017, 4365429. Doi: 10.1155/2017/4365429.
  18. Kaptchuk, T.J. (2000). The Web That Has No Weaver: Understanding Chinese Medicine. McGraw Hill; Anniversary Subsequent edition (16 gennaio 2000).
  19. Kleckner, I.R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, K., Quigley, K.S., Dickerson, B.C., & Barrett, L.F. (2017). Evidence for a large‐scale brain system supporting allostasis and interoception in humans. Nature Human Behavior, 1, 0069. https://doi.org/10.1038/s41562‐017‐0069 |www.nature.com/nathumbehav.
  20. Kong, J., Kaptchuk, T.J., Polich, G., Kirsch, I., Vangel, M., Zyloney, C., Rosen, B., & Gollub, R. (2009). Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia. Neuroimage, 45(3), 940‐9. Doi: 10.1016/j.neuroimage.2008.12.025.
  21. Langevin, H.M., & Wayne, P.M. (2018). What acupuncture can teach us about integrative medicine. New England Journal of Medicine, 378(24), 2233‐2235. Doi: 10.1089/ acm.2017.0366.
  22. Li, L., Yao, H., Wang, J., Li, Y., & Wang, Q. (2019). The Role of Chinese Medicine in Health Maintenance and Disease Prevention: Application of Constitution Theory. The American Journal of Chinese Medicine, 47(03), 495‐506. Doi: 10.1142/S0192415X19500253.
  23. Maciocia, G. (2007). I fondamenti della medicina cinese (2ª ed.). Elsevier Masson.
  24. Maturana, H.R., & Varela, F.J. (1980). Autopoiesis and Cognition: The Realization of the Living. Springer Dordrecht.
  25. Maturana, H.R., & Varela, F.J. (1980). Autopoiesi e Cognizione: La Realizzazione del Vivente. Marsilio. 7° ed. 2001. Biblioteca 978‐88‐317‐4778‐3.
  26. McEwen, B.S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338(3), 171‐179. Doi: 10.1056/NEJM199801153380307.
  27. McEwen, B.S. (2016). In pursuit of resilience: stress, epigenetics, and brain plasticity. Annals of the New York Academy of Sciences, 1373(1), 56‐64. Doi: 10.1111/nyas.13020.
  28. Morin, E. (2022). The Challenge of Complexity: Essays by Edgar Morin. Liverpool University Press.
  29. Napadow, V., Dhond, R.P., Kim, J., LaCount, L., Vangel, M., Harris, R.E., Kettner, N., & Park, K. (2009). Brain encoding of acupuncture sensation‐coupling on‐line rating with fMRI. Neuroimage, 47(3), 1055‐65. Doi: 10.1016/j.neuroimage.2009.05.079.
  30. Paulus, M.P., & Stein, M.B. (2006). An insular view of anxiety. Biol. Psychiatry, 60(4), 383‐7. Doi: 10.1016/j.biopsych.2006.03.042.
  31. Paulus, M.P., & Stein, M.B. (2010). Interoception in anxiety and depression. Brain Struct Funct, 214(5‐6), 451‐63. Doi: 10.1007/s00429‐010‐0258‐9.
  32. Seth, A.K., & Friston, K.J. (2016). Active interoceptive inference and the emotional brain. Philos Trans R Soc Lond B Biol Sci., 371(1708), 20160007. Doi: 10.1098/rstb.2016.0007.
  33. Seth, A.K., & Tsakiris, M. (2018). Being a Beast Machine: The Somatic Basis of Selfhood. Trends Cogn Sci., 22(11), 969‐981. Doi: 10.1016/j.tics.2018.08.008.
  34. Shaffer, C., Westlin, C., Quigley, K.S., Whitfield‐Gabrieli, S., & Barrett, L.F. (2022). Allostasis, Action, and Affect in Depression: Insights from the Theory of Constructed Emotion. Annu. Rev. Clin. Psychol., 18, 553‐80. Doi: 10.1146/annurev‐clinpsy‐081219‐115627.
  35. Spinoza, B. (1677). Ethics. (E. Curley, Trans., 1985). Princeton University Press 1994.
  36. Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In S. Fisher & J. Reason (Eds.), Handbook of life stress, cognition and health (pp. 629-649). Hoboken, NJ: John Wiley & Sons.
  37. Sterling, P. (2012). Allostasis: a model of predictive regulation. Physiol Behav., 106(1), 5‐15. Doi: 10.1016/j.physbeh.2011.06.004.
  38. Tabor, A., & Burr, C. (2019). Bayesian Learning Models of Pain: A Call to Action. Current Opinion in Behavioral Sciences, 26, 54‐61. Doi: 10.1016/j.cobeha.2018.10.006.
  39. Tang, Y.‐Y., Hölzel, B.K., & Posner, M.I. (2015). The neuroscience of mindfulness meditation. Nature Reviews Neuroscience, 16(4), 213‐225. Doi: 10.1038/nrn3916.
  40. Varela, F.J., Thompson, E., & Rosch, E. (1991). The Embodied Mind: Cognitive Science and Human Experience. MIT Press; New edition (1992).
  41. Wang. X.‐H., Xu, D.‐Q., Chen, Y.‐Y., Yue, S.‐J., Fu, R.‐J., Huang, L., & Tang, Y.‐P. (2022). Traditional Chinese Medicine: A promising strategy to regulate inflammation, intestinal disorders and impaired immune function due to sepsis. Front. Pharmacol., 13, 952938. Doi: 10.3389/fphar.2022.952938.
  42. Ziemke, T. (2016). The body of knowledge: On the role of the living body in grounding embodied cognition. Biosystems, 148, 4‐11. Doi: 10.1016/j.biosystems.2016.08.005.